В Управление Росреестра по Москве за 11 месяцев 2017 года поступило 63 775 заявлений о невозможности государственной регистрации прав без личного участия правообладателя или его законного представителя. В ноябре подобным образом защитили свою недвижимость от мошеннических действий 4 579 столичных жителей.
Заявление о невозможности регистрации перехода, прекращения, ограничения права и обременения объекта недвижимости может подать каждый владелец недвижимости. Соответствующая запись вносится в Единый государственный реестр недвижимости (ЕГРН) и становится основанием для возврата без рассмотрения заявления, представленного иными лицами. Таким образом, запрет сделок с имуществом без личного участия ее собственника, направлен на снижение числа мошеннических операций с недвижимостью, заключаемых посредниками, которые действуют по доверенности. Обратиться с заявлением можно в любой из территориальных отделов МФЦ или направить через личный кабинет на сайте Росреестра. Срок внесения записи – не более 5 рабочих дней. Руководитель Управления Росреестра по Москве Игорь Майданов: «Заявить о невозможности каких-либо регистрационных действий со своей недвижимостью без личного участия – это бесплатная возможность дополнительно защитить свою собственность. Безусловно, регистраторы в силу своих компетенций всегда проверяют подлинность сделки. Однако мы не вправе отказать в проведении регистрационных действий в том случае, если заявителем предоставлены надлежащие документы. А если они заверены нотариусом, мы обязаны учитывать их как достоверные. При наличии пометки в ЕГРН об обязательном личном участии правообладателя все заявления о проведении регистрации, поступившие от иного лица будут возвращаться без рассмотрения».
Аннулировать запись в ЕГРН о невозможности государственной регистрации без личного участия правообладателя можно при подаче собственником заявления об отзыве ранее поданного заявления или на основании вступившего в силу судебного акта.
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Ipamorelin and sermorelin are two peptide hormones that have gained attention for their roles in stimulating growth hormone release.
Although they share a common goal of enhancing the body’s natural production of growth hormone, they differ markedly in structure, mechanism of action, duration of effect, and
clinical application. Understanding these differences is essential when considering
combination therapy or choosing between them for specific
therapeutic objectives.
Sermorelin Therapy Can Be Combined With Ipamorelin Therapy
When used together, sermorelin and ipamorelin can create a synergistic environment that maximizes growth hormone secretion while minimizing potential side effects.
Sermorelin, a synthetic analogue of growth hormone-releasing hormone (GHRH),
works by binding to GHRH receptors in the pituitary gland,
prompting the release of endogenous growth hormone. Ipamorelin, on the other hand,
is a selective ghrelin receptor agonist that stimulates growth hormone secretion through
a different pathway. Because they target distinct receptors and mechanisms,
combining them can lead to a more robust and sustained increase in circulating growth
hormone levels.
A typical combination protocol might involve administering sermorelin early
in the day to take advantage of its peak effect during the
natural circadian rhythm of growth hormone release. Ipamorelin could then be given later in the
afternoon or evening to maintain elevated levels when endogenous secretion naturally wanes.
This staggered approach can help mimic physiological patterns more closely than either peptide alone, potentially improving outcomes such as improved sleep quality, better muscle recovery, and enhanced metabolic
health.
However, clinicians must monitor for overlapping side effects, especially those related to
growth hormone excess such as edema or joint pain. Blood tests
measuring insulin-like growth factor 1 (IGF-1) levels can provide a useful indicator of overall growth hormone
activity and help fine-tune dosing schedules.
By adjusting the timing and dosage of each peptide, practitioners can harness their complementary benefits while
keeping adverse effects in check.
What Is the Difference Between Sermorelin and
Ipamorelin?
Sermorelin dianabol steroid before and after ipamorelin differ on several key
fronts: chemical structure, receptor specificity, half-life, potency,
side-effect profile, and clinical use cases. Below is a detailed comparison that clarifies these distinctions:
Chemical Composition and Origin
Sermorelin is a 23-residue synthetic peptide that mimics the natural growth hormone-releasing hormone (GHRH).
Its sequence closely resembles the active portion of GHRH, allowing it to bind effectively to GHRH receptors in the pituitary gland.
Ipamorelin, by contrast, is a pentapeptide with the amino acid sequence His-D-Ala-Lys-Pro-Gly.
It was designed as a selective ghrelin receptor agonist, specifically targeting
the growth hormone secretagogue receptor (GHS-R1a).
Receptor Target and Mechanism of Action
Sermorelin’s primary action is through GHRH receptors; it stimulates pituitary cells to secrete endogenous growth hormone in a manner that mirrors natural hormonal release.
Ipamorelin works by binding to ghrelin receptors, which also trigger growth hormone secretion but do so via a different intracellular
signaling cascade. Because of this divergence, ipamorelin can act on tissues beyond the pituitary and may have broader
metabolic effects.
Pharmacokinetics (Half-Life)
Sermorelin has a relatively short half-life of
about 30 to 45 minutes when administered subcutaneously.
This necessitates multiple injections throughout the day or
at strategic times to maintain adequate stimulation. Ipamorelin’s half-life is shorter
still, around 20 to 30 minutes, but its potency allows for lower doses and potentially fewer injections
per cycle.
Potency and Dose Requirements
Due to its high affinity for GHS-R1a receptors, ipamorelin can be effective at lower
concentrations compared with sermorelin. A typical dose of ipamorelin might range from
200 to 300 micrograms per injection, whereas sermorelin often requires 100 to 150 micrograms per injection. The lower dosage for ipamorelin translates into reduced
cost and less frequent dosing.
Side-Effect Profile
Both peptides are generally well tolerated, but their side-effect profiles differ
slightly. Sermorelin can occasionally cause mild nausea or headache, likely related to
its influence on the central nervous system through
GHRH pathways. Ipamorelin may induce transient increases in appetite, as it
mimics ghrelin’s «hunger hormone» activity, though this
effect is typically mild and short-lived.
Clinical Applications
Sermorelin is frequently used for diagnostic purposes
to evaluate growth hormone deficiency, especially in children or adults
with suspected pituitary dysfunction. It is also employed therapeutically in patients with idiopathic growth
hormone deficiency, where it can replace or supplement
missing endogenous hormone. Ipamorelin finds broader
use in anti-aging protocols, athletic performance enhancement, and
metabolic disorders. Its ability to selectively stimulate growth hormone without significant prolactin release makes it attractive for individuals who require
prolonged GH stimulation but wish to avoid potential side effects such as
sexual dysfunction or increased lactation.
Regulatory Status
Sermorelin is approved by regulatory bodies in some countries
for diagnostic testing of growth hormone deficiency and, in certain jurisdictions,
for therapeutic use in adults with proven deficiency. Ipamorelin remains largely classified as a research chemical in many regions,
lacking formal approval for medical indications.
This status affects availability, pricing, and the legal framework under which it can be prescribed or sold.
Practical Considerations
For patients who need sustained growth hormone stimulation over long periods,
ipamorelin’s lower dose requirement may reduce injection volume and improve compliance.
Sermorelin’s ability to mimic natural circadian patterns makes it a good choice for
patients undergoing hormonal replacement
therapy where physiological timing is critical.
When used together, the two peptides can offset each other’s limitations:
sermorelin provides the initial surge early in the day, while ipamorelin maintains levels during evening hours.
In summary, sermorelin and ipamorelin are complementary tools that harness distinct biological pathways to stimulate growth hormone
release. Their differences—ranging from receptor specificity and potency to
side-effect profiles and regulatory status—guide clinicians in selecting the most appropriate therapy or designing combination regimens tailored to individual patient needs.
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